Assessment of Structural Intolerance and Durability
General Structure Information 4jiz MOB1A human mob1-phosphopeptide complex 2.1Å AUTH J.M.ROCK,D.LIM,L.STACH,R.W.OGRODOWICZ,J.M.KECK,M.H.JONES,AUTH 2 C.C.WONG,J.R.YATES,M.WINEY,S.J.SMERDON,M.B.YAFFE,A.AMONTITL ACTIVATION OF THE YEAST HIPPO PATHWAY BYTITL 2 PHOSPHORYLATION-DEPENDENT ASSEMBLY OF SIGNALING COMPLEXES.REF SCIENCE V. 340 871 2013REFN ISSN 0036-8075PMID 23579499DOI 10.1126/SCIENCE.1235822 Variant Set Distributions Mapped Variants
General Structure Information 3dcy C12orf5 crystal structure a tp53-induced glycolysis and apoptosis regulator protein from homo sapiens. 1.75Å AUTH J.G.MCCOY,C.A.BINGMAN,G.E.WESENBERG,AUTH 2 G.N.PHILLIPS JR.TITL CRYSTAL STRUCTURE A TP53-INDUCED GLYCOLYSIS ANDTITL 2 APOPTOSIS REGULATOR PROTEIN FROM HOMO SAPIENS.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2v4u CTPS2 human ctp synthetase 2 – glutaminase domain in complex with 5-oxo-l-norleucine 2.3Å AUTH M.WELIN,M.MOCHE,J.ANDERSSON,C.H.ARROWSMITH,AUTH 2 H.BERGLUND,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,AUTH 4 A.JOHANSSON,I.JOHANSSON,T.KARLBERG,T.KOTENYOVA,AUTH 5 L.LEHTIO,M.E.NILSSON,T.NYMAN,K.OLESEN,C.PERSSON,AUTH 6 J.SAGEMARK,H.SCHUELER,A.G.THORSELL,L.TRESAUGUES,AUTH 7 S.VAN DEN BERG,M.WISNIEWSKA,J.WEIGELT,M.WIKSTROM,AUTH 8 P.NORDLUNDTITL HUMAN CTP SYNTHETASE 2 – GLUTAMINASE DOMAIN INTITL 2 COMPLEX WITH 5-OXO-L-NORLEUCINEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dkz GAREM solution structure of the sam_pnt-domain of the hypothetical protein loc64762 -1.0Å AUTH A.K.GORONCY,M.SATO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SAM_PNT-DOMAIN OF THETITL 2 HYPOTHETICAL PROTEIN LOC64762REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dk6 PARP11 solution structure of wwe domain in poly (adp-ribose) polymerase family, member 11 (parp 11) -1.0Å AUTH F.HE,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TERADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF WWE DOMAIN IN POLYTITL 2 (ADP-RIBOSE) POLYMERASE FAMILY, MEMBER 11 (PARP 11)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3zqs FANCL human fancl central domain 2.0Å AUTH C.HODSON,A.R.COLE,L.P.LEWIS,J.A.MILES,AUTH 2 A.PURKISS-TREW,H.WALDENTITL STRUCTURAL ANALYSIS OF HUMAN FANCL, THE E3 LIGASETITL 2 IN THE FANCONI ANEMIA PATHWAY.REF J.BIOL.CHEM. V. 286 32628 2011REFN ISSN 0021-9258PMID 21775430DOI 10.1074/JBC.M111.244632 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ai6 PHPT1 solution structure of human phosphohistidine phosphatase 1 -1.0Å AUTH W.GONG,Y.LI,G.CUI,J.HU,H.FANG,C.JIN,B.XIATITL SOLUTION STRUCTURE AND CATALYTIC MECHANISM OFTITL 2 HUMAN PROTEIN HISTIDINE PHOSPHATASE 1.REF BIOCHEM.J. V. 418 337 2009REFN ISSN 0264-6021PMID 18991813DOI 10.1042/BJ20081571 Variant Set Distributions Mapped Variants
General Structure Information 2ee0 PCDH9 solution structures of the ca domain of human protocadherin 9 -1.0Å AUTH M.SATO,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURES OF THE CA DOMAIN OF HUMANTITL 2 PROTOCADHERIN 9REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4b6l PLK3 discovery of oral polo-like kinase (plk) inhibitors with enhanced selectivity profile using residue targeted drug design 1.9Å AUTH K.BROWN,J.D.CHARRIER,S.DURRANT,M.GRIFFITHS,C.HUDSON,D.KAY,AUTH 2 R.KNEGTEL,M.ODONNELL,F.PIERARD,H.TWIN,P.WEBER,S.YOUNGTITL DISCOVERY OF ORAL POLO-LIKE KINASE (PLK) INHIBITORS WITHTITL 2 ENHANCED SELECTIVITY PROFILE USING RESIDUE TARGETED DRUGTITL 3 DESIGNREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dah UBQLN3 solution structure of the c-terminal uba domain in the human ubiquilin 3 -1.0Å AUTH C.ZHAO,T.KIGAWA,M.SATO,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C-TERMINAL UBA DOMAIN INTITL 2 THE HUMAN UBIQUILIN 3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants