Assessment of Structural Intolerance and Durability
General Structure Information 2xqn ENAH complex of the 2nd and 3rd lim domains of tes with the evh1 domain of mena and the n-terminal domain of actin-like protein arp7a 2.62Å AUTH B.BOEDA,P.P.KNOWLES,D.C.BRIGGS,J.MURRAY-RUST,E.SORIANO,AUTH 2 B.K.GARVALOV,N.Q.MCDONALD,M.WAYTITL MOLECULAR RECOGNITION OF THE TES LIM2-3 DOMAINS BY THETITL 2 ACTIN-RELATED PROTEIN ARP7A.REF J.BIOL.CHEM. V. 286 11543 2011REFN ISSN 0021-9258PMID 21278383DOI […]
General Structure Information 1va9 DSCAML1 solution structure of the second fniii domain of dscaml1 protein -1.0Å AUTH X.-R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND FNIII DOMAIN OFTITL 2 DSCAML1 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2pnt GRASP crystal structure of the pdz domain of human grasp (grp1) in complex with the c-terminal peptide of the metabotropic glutamate receptor type 1 2.15Å AUTH J.ELKINS,E.PAPAGRIGORIOU,C.COOPER,C.GILEADI,AUTH 2 J.UPPENBERG,J.BRAY,F.VON DELFT,A.C.W.PIKE,AUTH 3 E.UGOCHUKWU,C.UMEANO,O.GILEADI,A.EDWARDS,AUTH 4 C.H.ARROWSMITH,J.WEIGELT,M.SUNDSTROM,D.A.DOYLE,AUTH 5 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF HUMAN GRASPTITL 2 (GRP1) IN […]
General Structure Information 4if8 SERPINA12 structure of vaspin 2.08Å AUTH J.T.HEIKER,N.KLOTING,P.KOVACS,E.B.KUETTNER,N.STRATER,AUTH 2 S.SCHULTZ,M.KERN,M.STUMVOLL,M.BLUHER,A.G.BECK-SICKINGERTITL VASPIN INHIBITS KALLIKREIN 7 BY SERPIN MECHANISMREF CELL.MOL.LIFE SCI. V. 70 2569 2013REFN ISSN 1420-682XPMID 23370777DOI 10.1007/S00018-013-1258-8 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2eef PPP1R3B solution structure of the cbm_21 domain from human protein phosphatase 1, regulatory (inhibitor) subunit 3b -1.0Å AUTH T.TOMIZAWA,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE CBM_21 DOMAIN FROM HUMANTITL 2 PROTEIN PHOSPHATASE 1, REGULATORY (INHIBITOR)TITL 3 SUBUNIT 3BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2okv DTD1 c-myc dna unwinding element binding protein 2.0Å AUTH M.KEMP,B.BAE,J.P.YU,M.GHOSH,M.LEFFAK,S.K.NAIRTITL STRUCTURE AND FUNCTION OF THE C-MYC DNA-UNWINDINGTITL 2 ELEMENT-BINDING PROTEIN DUE-B.REF J.BIOL.CHEM. V. 282 10441 2007REFN ISSN 0021-9258PMID 17264083DOI 10.1074/JBC.M609632200 Variant Set Distributions Mapped Variants
General Structure Information 2wt8 MCPH1 structure of the n-terminal brct domain of human microcephalin (mcph1) 1.6Å AUTH M.W.RICHARDS,J.W.C.LEUNG,S.M.ROE,J.CHEN,R.BAYLISSTITL A POCKET ON THE SURFACE OF THE N-TERMINAL BRCTTITL 2 DOMAIN OF MCPH1 IS REQUIRED TO PREVENT ABNORMALTITL 3 CHROMOSOME CONDENSATION.REF J.MOL.BIOL. V. 395 908 2010REFN ISSN 0022-2836PMID 19925808DOI 10.1016/J.JMB.2009.11.029 Variant Set Distributions Pathogenic Proximity Analysis Mapped […]
General Structure Information 4lev MB21D1 structure of human cgas 1.95Å AUTH X.LI,C.SHU,G.YI,C.T.CHATON,C.L.SHELTON,J.DIAO,X.ZUO,C.C.KAO,AUTH 2 A.B.HERR,P.LITITL CYCLIC GMP-AMP SYNTHASE IS ACTIVATED BY DOUBLE-STRANDEDTITL 2 DNA-INDUCED OLIGOMERIZATION.REF IMMUNITY V. 39 1019 2013REFN ISSN 1074-7613PMID 24332030DOI 10.1016/J.IMMUNI.2013.10.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2daf IQUB solution structure of the novel identified ubiquitin-like domain in the human hypothetical protein flj35834 -1.0Å AUTH C.ZHAO,T.KIGAWA,K.SAITO,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE NOVEL IDENTIFIEDTITL 2 UBIQUITIN-LIKE DOMAIN IN THE HUMAN HYPOTHETICALTITL 3 PROTEIN FLJ35834REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4mwi MLKL crystal structure of the human mlkl pseudokinase domain 1.7Å AUTH J.M.MURPHY,I.S.LUCET,J.M.HILDEBRAND,M.C.TANZER,S.N.YOUNG,AUTH 2 P.SHARMA,G.LESSENE,W.S.ALEXANDER,J.J.BABON,J.SILKE,AUTH 3 P.E.CZABOTARTITL INSIGHTS INTO THE EVOLUTION OF DIVERGENT NUCLEOTIDE-BINDINGTITL 2 MECHANISMS AMONG PSEUDOKINASES REVEALED BY CRYSTALTITL 3 STRUCTURES OF HUMAN AND MOUSE MLKL.REF BIOCHEM.J. V. 457 369 2014REFN ISSN 0264-6021PMID 24219132DOI 10.1042/BJ20131270 Variant Set Distributions Ripley’s K […]