Assessment of Structural Intolerance and Durability
General Structure Information 3kt9 APTX aprataxin fha domain 1.65Å AUTH O.J.BECHEREL,B.JAKOB,A.L.CHERRY,N.GUEVEN,M.FUSSER,AUTH 2 A.W.KIJAS,C.PENG,S.KATYAL,P.J.MCKINNON,J.CHEN,AUTH 3 B.EPE,S.J.SMERDON,G.TAUCHER-SCHOLZ,M.F.LAVINTITL CK2 PHOSPHORYLATION-DEPENDENT INTERACTION BETWEENTITL 2 APRATAXIN AND MDC1 IN THE DNA DAMAGE RESPONSE.REF NUCLEIC ACIDS RES. V. 38 1489 2010REFN ISSN 0305-1048PMID 20008512DOI 10.1093/NAR/GKP1149 Variant Set Distributions Mapped Variants
General Structure Information 4fmw TRMT10A crystal structure of methyltransferase domain of human rna (guanine-9- ) methyltransferase domain containing protein 2 2.0Å AUTH H.ZENG,A.DONG,P.LOPPNAU,W.TEMPEL,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,H.WUTITL CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMAN RNATITL 2 (GUANINE-9-) METHYLTRANSFERASE DOMAIN CONTAINING PROTEIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4n48 CMTR1 cap-specific mrna (nucleoside-2-o-)-methyltransferase 1 protein in complex with capped rna fragment 2.7Å AUTH M.SMIETANSKI,M.WERNER,E.PURTA,K.H.KAMINSKA,J.STEPINSKI,AUTH 2 E.DARZYNKIEWICZ,M.NOWOTNY,J.M.BUJNICKITITL STRUCTURAL ANALYSIS OF HUMAN 2-O-RIBOSE METHYLTRANSFERASESTITL 2 INVOLVED IN MRNA CAP STRUCTURE FORMATION.REF NAT COMMUN V. 5 3004 2014REFN ESSN 2041-1723PMID 24402442DOI 10.1038/NCOMMS4004 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 2p5s RASEF rab domain of human rasef in complex with gdp 2.15Å AUTH H.ZHU,J.WANG,Y.SHEN,W.TEMPEL,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL RAB DOMAIN OF HUMAN RASEF IN COMPLEX WITH GDPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2zb7 PTGR2 crystal structure of human 15-ketoprostaglandin delta-13- reductase in complex with nadph and nicotinamide 1.8Å AUTH Y.H.WU,T.P.KO,R.T.GUO,S.M.HU,L.M.CHUANG,A.H.J.WANGTITL STRUCTURAL BASIS FOR CATALYTIC AND INHIBITORYTITL 2 MECHANISMS OF HUMAN PROSTAGLANDIN REDUCTASE PTGR2.REF STRUCTURE V. 16 1714 2008REFN ISSN 0969-2126PMID 19000823DOI 10.1016/J.STR.2008.09.007 Variant Set Distributions Mapped Variants
General Structure Information 2dm8 INADL solution structure of the eighth pdz domain of human inad- like protein -1.0Å AUTH K.INOUE,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE EIGHTH PDZ DOMAIN OFTITL 2 HUMAN INAD-LIKE PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3rco TDRD7 crystal structure of a conserved motif in human tdrd7 1.8Å AUTH C.XU,A.DONG,J.R.WALKER,R.LAM,Y.GUO,C.BIAN,Y.LI,C.BOUNTRA,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,J.MIN,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF A CONSERVED MOTIF IN HUMAN TDRD7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4geb AADAT kynurenine aminotransferase ii inhibitors 2.15Å AUTH A.B.DOUNAY,M.ANDERSON,B.M.BECHLE,E.EVRARD,X.GAN,J.Y.KIM,AUTH 2 L.A.MCALLISTER,J.PANDIT,S.RONG,M.A.SALAFIA,J.B.TUTTLE,AUTH 3 L.E.ZAWADZKE,P.R.VERHOESTTITL PF-04859989 AS A TEMPLATE FOR STRUCTURE-BASED DRUG DESIGN:TITL 2 IDENTIFICATION OF NEW PYRAZOLE SERIES OF IRREVERSIBLE KAT IITITL 3 INHIBITORS WITH IMPROVED LIPOPHILIC EFFICIENCY.REF BIOORG.MED.CHEM.LETT. V. 23 1961 2013REFN ISSN 0960-894XPMID 23466229DOI 10.1016/J.BMCL.2013.02.039 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1mi1 NBEA crystal structure of the ph-beach domain of human neurobeachin 2.9Å AUTH G.JOGL,Y.SHEN,D.GEBAUER,J.LI,K.WIEGMANN,H.KASHKAR,AUTH 2 M.KRONKE,L.TONGTITL CRYSTAL STRUCTURE OF THE BEACH DOMAIN REVEALS ANTITL 2 UNUSUAL FOLD AND EXTENSIVE ASSOCIATION WITH ATITL 3 NOVEL PH DOMAIN.REF EMBO J. V. 21 4785 2002REFN ISSN 0261-4189PMID 12234919DOI 10.1093/EMBOJ/CDF502 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3cyn GPX8 the structure of human gpx8 2.0Å AUTH K.L.KAVANAGH,C.JOHANSSON,W.W.YUE,G.KOCHAN,U.OPPERMANNTITL THE STRUCTURE OF HUMAN GPX8REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants