Assessment of Structural Intolerance and Durability
General Structure Information 2ct2 TRIM32 solution structure of the ring domain of the tripartite motif protein 32 -1.0Å AUTH K.MIYAMOTO,N.TOCHIO,M.SATO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RING DOMAIN OF THETITL 2 TRIPARTITE MOTIF PROTEIN 32REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4oav RNASEL complete human rnase l in complex with 2-5a (5-ppp heptamer), amppcp and rna substrate. 2.1Å AUTH Y.HAN,J.DONOVAN,S.RATH,G.WHITNEY,A.CHITRAKAR,A.KORENNYKHTITL STRUCTURE OF HUMAN RNASE L REVEALS THE BASIS FOR REGULATEDTITL 2 RNA DECAY IN THE IFN RESPONSE.REF SCIENCE V. 343 1244 2014REFN ISSN 0036-8075PMID 24578532DOI 10.1126/SCIENCE.1249845 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1xdv SOS1 experimentally phased structure of human the son of sevenless protein at 4.1 ang. 4.1Å AUTH H.SONDERMANN,S.M.SOISSON,S.BOYKEVISCH,S.S.YANG,AUTH 2 D.BAR-SAGI,J.KURIYANTITL STRUCTURAL ANALYSIS OF AUTOINHIBITION IN THE RASTITL 2 ACTIVATOR SON OF SEVENLESS.REF CELL(CAMBRIDGE,MASS.) V. 119 393 2004REFN ISSN 0092-8674PMID 15507210DOI 10.1016/J.CELL.2004.10.005 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3sag EXOSC10 crystal structure of the human rrp6 catalytic domain with d313n mutation in the active site 2.7Å AUTH K.JANUSZYK,Q.LIU,C.D.LIMATITL ACTIVITIES OF HUMAN RRP6 AND STRUCTURE OF THE HUMAN RRP6TITL 2 CATALYTIC DOMAIN.REF RNA V. 17 1566 2011REFN ISSN 1355-8382PMID 21705430DOI 10.1261/RNA.2763111 Variant Set Distributions Mapped Variants
General Structure Information 2la5 FMR1 rna duplex-quadruplex junction complex with fmrp rgg peptide -1.0Å AUTH A.T.PHAN,V.KURYAVYI,J.C.DARNELL,A.SERGANOV,A.MAJUMDAR,AUTH 2 S.ILIN,T.RASLIN,A.POLONSKAIA,C.CHEN,D.CLAIN,R.B.DARNELL,AUTH 3 D.J.PATELTITL STRUCTURE-FUNCTION STUDIES OF FMRP RGG PEPTIDE RECOGNITIONTITL 2 OF AN RNA DUPLEX-QUADRUPLEX JUNCTION.REF NAT.STRUCT.MOL.BIOL. V. 18 796 2011REFN ISSN 1545-9993PMID 21642970DOI 10.1038/NSMB.2064 Variant Set Distributions Mapped Variants
General Structure Information 2lk9 BST2 structure of bst-2/tetherin transmembrane domain -1.0Å AUTH M.SKASKO,Y.WANG,Y.TIAN,A.TOKAREV,J.MUNGUIA,A.RUIZ,AUTH 2 E.B.STEPHENS,S.J.OPELLA,J.GUATELLITITL HIV-1 VPU PROTEIN ANTAGONIZES INNATE RESTRICTION FACTORTITL 2 BST-2 VIA LIPID-EMBEDDED HELIX-HELIX INTERACTIONS.REF J.BIOL.CHEM. V. 287 58 2012REFN ISSN 0021-9258PMID 22072710DOI 10.1074/JBC.M111.296772 Variant Set Distributions Mapped Variants
General Structure Information 2dt7 SF3A3 solution structure of the second surp domain of human splicing factor sf3a120 in complex with a fragment of human splicing factor sf3a60 -1.0Å AUTH K.KUWASAKO,F.HE,M.INOUE,A.TANAKA,S.SUGANO,AUTH 2 P.GUENTERT,Y.MUTO,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE SURP DOMAINS AND THETITL 2 SUBUNIT-ASSEMBLY MECHANISM WITHIN THE SPLICINGTITL 3 FACTOR SF3A COMPLEX IN 17S U2 SNRNPREF STRUCTURE […]
General Structure Information 2gf5 FADD structure of intact fadd (mort1) -1.0Å AUTH P.E.CARRINGTON,C.SANDU,Y.WEI,J.M.HILL,G.MORISAWA,AUTH 2 T.HUANG,E.GAVATHIOTIS,Y.WEI,M.H.WERNERTITL THE STRUCTURE OF FADD AND ITS MODE OF INTERACTIONTITL 2 WITH PROCASPASE-8REF MOL.CELL V. 22 599 2006REFN ISSN 1097-2765PMID 16762833DOI 10.1016/J.MOLCEL.2006.04.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1avo PSME1 proteasome activator reg(alpha) 2.8Å AUTH J.R.KNOWLTON,S.C.JOHNSTON,F.G.WHITBY,C.REALINI,AUTH 2 Z.ZHANG,M.RECHSTEINER,C.P.HILLTITL STRUCTURE OF THE PROTEASOME ACTIVATOR REGALPHATITL 2 (PA28ALPHA).REF NATURE V. 390 639 1997REFN ISSN 0028-0836PMID 9403698DOI 10.1038/37670 Variant Set Distributions Mapped Variants
General Structure Information 4hzs TNK2 crystal structure of ack1 kinase domain with c-terminal sh3 domain 3.23Å AUTH K.S.GAJIWALA,K.MAEGLEY,R.FERRE,Y.A.HE,X.YUTITL ACK1: ACTIVATION AND REGULATION BY ALLOSTERY.REF PLOS ONE V. 8 53994 2013REFN ESSN 1932-6203PMID 23342057DOI 10.1371/JOURNAL.PONE.0053994 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants