Assessment of Structural Intolerance and Durability
General Structure Information 2w5a NEK2 human nek2 kinase adp-bound 1.55Å AUTH I.WESTWOOD,D.M.CHEARY,J.E.BAXTER,M.W.RICHARDS,AUTH 2 R.L.VAN MONTFORT,A.M.FRY,R.BAYLISSTITL INSIGHTS INTO THE CONFORMATIONAL VARIABILITY ANDTITL 2 REGULATION OF HUMAN NEK2 KINASE.REF J.MOL.BIOL. V. 386 476 2009REFN ISSN 0022-2836PMID 19124027DOI 10.1016/J.JMB.2008.12.033 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2dat SMARCA2 solution structure of the bromodomain of human swi/snf related matrix associated actin dependent regulator of cromatin subfamily a member 2 -1.0Å AUTH M.YONEYAMA,T.KIGAWA,K.SAITO,N.TOCHIO,S.KOSHIBA,AUTH 2 M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE BROMODOMAIN OF HUMANTITL 2 SWI/SNF RELATED MATRIX ASSOCIATED ACTIN DEPENDENTTITL 3 REGULATOR OF CROMATIN SUBFAMILY A MEMBER 2REF TO BE PUBLISHEDREFN […]
General Structure Information 4f7s CDK8 crystal structure of human cdk8/cycc in the dmg-in conformation 2.2Å AUTH E.V.SCHNEIDER,J.BOTTCHER,R.HUBER,K.MASKOS,L.NEUMANNTITL STRUCTURE-KINETIC RELATIONSHIP STUDY OF CDK8/CYCC SPECIFICTITL 2 COMPOUNDS.REF PROC.NATL.ACAD.SCI.USA V. 110 8081 2013REFN ISSN 0027-8424PMID 23630251DOI 10.1073/PNAS.1305378110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1mj4 SUOX crystal structure analysis of the cytochrome b5 domain of human sulfite oxidase 1.2Å AUTH M.J.RUDOLPH,J.L.JOHNSON,K.V.RAJAGOPALAN,C.KISKERTITL THE 1.2 A STRUCTURE OF THE HUMAN SULFITE OXIDASE CYTOCHROMETITL 2 B(5) DOMAIN.REF ACTA CRYSTALLOGR.,SECT.D V. 59 1183 2003REFN ISSN 0907-4449PMID 12832761DOI 10.1107/S0907444903009934 Variant Set Distributions Mapped Variants
General Structure Information 2o10 CSRP3 solution structure of the n-terminal lim domain of mlp/crp3 -1.0Å AUTH T.SCHALLUS,G.STIER,K.FEHER,C.MUHLE-GOLLTITL STRUCTURE OF THE MUSCULAR LIM PROTEIN MLP AND ITSTITL 2 INTERACTION WITH ACTININREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2o13 CSRP3 solution structure of the c-terminal lim domain of mlp/crp3 -1.0Å AUTH T.SCHALLUS,G.STIER,K.FEHER,C.MUHLE-GOLLTITL STRUCTURE OF THE MUSCULAR LIM PROTEIN MLP AND ITSTITL 2 INTERACTION WITH ACTININREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4a6e ASMT crystal structure of human n-acetylserotonin methyltransferase (asmt) in complex with sam and n-acetylserotonin 2.7Å AUTH H.G.BOTROS,P.LEGRAND,C.PAGAN,V.BONDET,P.WEBER,AUTH 2 M.BEN-ABDALLAH,N.LEMIERE,G.HUGUET,J.BELLALOU,E.MARONDE,AUTH 3 P.BEGUIN,A.HAOUZ,W.SHEPARD,T.BOURGERONTITL CRYSTAL STRUCTURE AND FUNCTIONAL MAPPING OF HUMAN ASMT, THETITL 2 LAST ENZYME OF THE MELATONIN SYNTHESIS PATHWAY.REF J.PINEAL RES. V. 54 46 2013REFN ISSN 0742-3098PMID 22775292DOI 10.1111/J.1600-079X.2012.01020.X Variant Set Distributions […]
General Structure Information 3e0j POLD2 x-ray structure of the complex of regulatory subunits of human dna polymerase delta 3.0Å AUTH A.G.BARANOVSKIY,N.D.BABAYEVA,V.G.LISTON,AUTH 2 I.B.ROGOZIN,E.V.KOONIN,Y.I.PAVLOV,D.G.VASSYLYEV,AUTH 3 T.H.TAHIROVTITL X-RAY STRUCTURE OF THE COMPLEX OF REGULATORYTITL 2 SUBUNITS OF HUMAN DNA POLYMERASE DELTA.REF CELL CYCLE V. 7 3026 2008REFN ISSN 1538-4101PMID 18818516 Variant Set Distributions Mapped Variants
General Structure Information 1t77 LRBA crystal structure of the ph-beach domains of human lrba/bgl 2.4Å AUTH D.GEBAUER,J.LI,G.JOGL,Y.SHEN,D.G.MYSZKA,L.TONGTITL CRYSTAL STRUCTURE OF THE PH-BEACH DOMAINS OF HUMANTITL 2 LRBA/BGLREF BIOCHEMISTRY V. 43 14873 2004REFN ISSN 0006-2960PMID 15554694DOI 10.1021/BI049498Y Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2eyz CRK ct10-regulated kinase isoform ii -1.0Å AUTH Y.KOBASHIGAWA,M.SAKAI,M.NAITO,M.YOKOCHI,H.KUMETA,AUTH 2 Y.MAKINO,K.OGURA,S.TANAKA,F.INAGAKITITL STRUCTURAL BASIS FOR THE TRANSFORMING ACTIVITY OFTITL 2 HUMAN CANCER-RELATED SIGNALING ADAPTOR PROTEIN CRK.REF NAT.STRUCT.MOL.BIOL. V. 14 503 2007REFN ISSN 1545-9993PMID 17515907DOI 10.1038/NSMB1241 Variant Set Distributions Mapped Variants