Assessment of Structural Intolerance and Durability
General Structure Information 4bkx MTA1 the structure of hdac1 in complex with the dimeric elm2-sant domain of mta1 from the nurd complex 3.0Å AUTH C.J.MILLARD,P.J.WATSON,I.CELARDO,Y.GORDIYENKO,S.M.COWLEY,AUTH 2 C.V.ROBINSON,L.FAIRALL,J.W.R.SCHWABETITL CLASS I HDACS SHARE A COMMON MECHANISM OF REGULATION BYTITL 2 INOSITOL PHOSPHATES.REF MOL.CELL V. 51 57 2013REFN ISSN 1097-2765PMID 23791785DOI 10.1016/J.MOLCEL.2013.05.020 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2xu7 RBBP4 structural basis for rbap48 binding to fog-1 1.9Å AUTH S.LEJON,S.Y.THONG,A.MURTHY,S.ALQARNI,N.V.MURZINA,G.A.BLOBEL,AUTH 2 E.D.LAUE,J.P.MACKAYTITL INSIGHTS INTO ASSOCIATION OF THE NURD COMPLEX WITH FOG-1TITL 2 FROM THE CRYSTAL STRUCTURE OF AN RBAP48-FOG- 1 COMPLEX.REF J.BIOL.CHEM. V. 286 1196 2011REFN ISSN 0021-9258PMID 21047798DOI 10.1074/JBC.M110.195842 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1aqc APBA1 x11 ptb domain-10mer peptide complex 2.3Å AUTH Z.ZHANG,C.H.LEE,V.MANDIYAN,J.P.BORG,B.MARGOLIS,AUTH 2 J.SCHLESSINGER,J.KURIYANTITL SEQUENCE-SPECIFIC RECOGNITION OF THETITL 2 INTERNALIZATION MOTIF OF THE ALZHEIMERS AMYLOIDTITL 3 PRECURSOR PROTEIN BY THE X11 PTB DOMAIN.REF EMBO J. V. 16 6141 1997REFN ISSN 0261-4189PMID 9321393DOI 10.1093/EMBOJ/16.20.6141 Variant Set Distributions Mapped Variants
General Structure Information 3vi8 PPARA human pprr alpha ligand binding domain in complex with a synthetic agonist aphm13 1.75Å AUTH N.KUWABARA,T.OYAMA,D.TOMIOKA,M.OHASHI,J.YANAGISAWA,AUTH 2 T.SHIMIZU,H.MIYACHITITL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPARS) HAVETITL 2 MULTIPLE BINDING POINTS THAT ACCOMMODATE LIGANDS IN VARIOUSTITL 3 CONFORMATIONS: PHENYLPROPANOIC ACID-TYPE PPAR LIGANDS BINDTITL 4 TO PPAR IN DIFFERENT CONFORMATIONS, DEPENDING ON THE SUBTYPEREF J.MED.CHEM. […]
General Structure Information 2qpw PRDM2 methyltransferase domain of human pr domain-containing protein 2 1.79Å AUTH H.WU,J.MIN,V.V.LUNIN,T.ANTOSHENKO,L.DOMBROVSKI,AUTH 2 H.ZENG,A.ALLALI-HASSANI,V.CAMPAGNA-SLATER,M.VEDADI,AUTH 3 C.H.ARROWSMITH,A.N.PLOTNIKOV,M.SCHAPIRATITL STRUCTURAL BIOLOGY OF HUMAN H3K9 METHYLTRANSFERASESREF PLOS ONE V. 5 E8570 2010REFN ESSN 1932-6203PMID 20084102DOI 10.1371/JOURNAL.PONE.0008570 Variant Set Distributions Mapped Variants
General Structure Information 2w5z KMT2A ternary complex of the mixed lineage leukaemia (mll1) set domain with the cofactor product s-adenosylhomocysteine and histone peptide. 2.2Å AUTH S.M.SOUTHALL,P.S.WONG,Z.ODHO,S.M.ROE,J.R.WILSONTITL STRUCTURAL BASIS FOR THE REQUIREMENT OF ADDITIONALTITL 2 FACTORS FOR MLL1 SET DOMAIN ACTIVITY ANDTITL 3 RECOGNITION OF EPIGENETIC MARKS.REF MOL.CELL V. 33 181 2009REFN ISSN 1097-2765PMID 19187761DOI 10.1016/J.MOLCEL.2008.12.029 […]
General Structure Information 2cfv PTPRJ crystal structure of human protein tyrosine phosphatase receptor type j 2.5Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.F.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2e50 SET crystal structure of set/taf-1beta/inhat 2.3Å AUTH S.MUTO,M.SENDA,Y.AKAI,L.SATO,T.SUZUKI,R.NAGAI,T.SENDA,AUTH 2 M.HORIKOSHITITL RELATIONSHIP BETWEEN THE STRUCTURE OF SET/TAF-IBETA/INHATTITL 2 AND ITS HISTONE CHAPERONE ACTIVITYREF PROC.NATL.ACAD.SCI.USA V. 104 4285 2007REFN ISSN 0027-8424PMID 17360516DOI 10.1073/PNAS.0603762104 Variant Set Distributions Mapped Variants
General Structure Information 2p8u HMGCS1 crystal structure of human 3-hydroxy-3-methylglutaryl coa synthase i 2.0Å AUTH N.SHAFQAT,A.TURNBULL,J.ZSCHOCKE,U.OPPERMANN,W.W.YUETITL CRYSTAL STRUCTURES OF HUMAN HMG-COA SYNTHASE ISOFORMSTITL 2 PROVIDE INSIGHTS INTO INHERITED KETOGENESIS DISORDERS ANDTITL 3 INHIBITOR DESIGN.REF J.MOL.BIOL. V. 398 497 2010REFN ISSN 0022-2836PMID 20346956DOI 10.1016/J.JMB.2010.03.034 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3bxm FOLH1 structure of an inactive mutant of human glutamate carboxypeptidase ii [gcpii(e424a)] in complex with n-acetyl-asp-glu (naag) 1.71Å AUTH V.KLUSAK,C.BARINKA,A.PLECHANOVOVA,P.MLCOCHOVA,J.KONVALINKA,AUTH 2 L.RULISEK,J.LUBKOWSKITITL REACTION MECHANISM OF GLUTAMATE CARBOXYPEPTIDASE II REVEALEDTITL 2 BY MUTAGENESIS, X-RAY CRYSTALLOGRAPHY, AND COMPUTATIONALTITL 3 METHODS.REF BIOCHEMISTRY V. 48 4126 2009REFN ISSN 0006-2960PMID 19301871DOI 10.1021/BI900220S Variant Set Distributions Ripley’s […]