Assessment of Structural Intolerance and Durability
General Structure Information 1esr CCL8 crystal structure of human monocyte chemotactic protein-2 2.0Å AUTH J.BLASZCZYK,E.V.COILLIE,P.PROOST,J.V.DAMME,AUTH 2 G.OPDENAKKER,G.D.BUJACZ,J.M.WANG,X.JITITL COMPLETE CRYSTAL STRUCTURE OF MONOCYTE CHEMOTACTICTITL 2 PROTEIN-2, A CC CHEMOKINE THAT INTERACTS WITHTITL 3 MULTIPLE RECEPTORS.REF BIOCHEMISTRY V. 39 14075 2000REFN ISSN 0006-2960PMID 11087354DOI 10.1021/BI0009340 Variant Set Distributions Mapped Variants
General Structure Information 3mmy RAE1 structural and functional analysis of the interaction between the nucleoporin nup98 and the mrna export factor rae1 1.65Å AUTH Y.REN,H.S.SEO,G.BLOBEL,A.HOELZTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE INTERACTIONTITL 2 BETWEEN THE NUCLEOPORIN NUP98 AND THE MRNA EXPORT FACTORTITL 3 RAE1.REF PROC.NATL.ACAD.SCI.USA V. 107 10406 2010REFN ISSN 0027-8424PMID 20498086DOI 10.1073/PNAS.1005389107 Variant Set […]
General Structure Information 4f8q BTN3A2 crystal structure of the human btn3a2 ectodomain 2.38Å AUTH A.PALAKODETI,A.SANDSTROM,L.SUNDARESAN,C.HARLY,S.NEDELLEC,AUTH 2 D.OLIVE,E.SCOTET,M.BONNEVILLE,E.J.ADAMSTITL THE MOLECULAR BASIS FOR MODULATION OF HUMANTITL 2 V(GAMMA)9V(DELTA)2 T CELL RESPONSES BY CD277/BUTYROPHILIN-3TITL 3 (BTN3A)-SPECIFIC ANTIBODIESREF J.BIOL.CHEM. V. 287 32780 2012REFN ISSN 0021-9258PMID 22846996DOI 10.1074/JBC.M112.384354 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1q1u FGF12 crystal structure of human fhf1b (fgf12b) 1.7Å AUTH S.K.OLSEN,M.GARBI,N.ZAMPIERI,A.V.ELISEENKOVA,AUTH 2 D.M.ORNITZ,M.GOLDFARB,M.MOHAMMADITITL FIBROBLAST GROWTH FACTOR (FGF) HOMOLOGOUS FACTORSTITL 2 SHARE STRUCTURAL BUT NOT FUNCTIONAL HOMOLOGY WITHTITL 3 FGFSREF J.BIOL.CHEM. V. 278 34226 2003REFN ISSN 0021-9258PMID 12815063DOI 10.1074/JBC.M303183200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1y8x UBE2M structural basis for recruitment of ubc12 by an e2-binding domain in nedd8s e1 2.4Å AUTH D.T.HUANG,A.PAYDAR,M.ZHUANG,M.B.WADDELL,J.M.HOLTON,AUTH 2 B.A.SCHULMANTITL STRUCTURAL BASIS FOR RECRUITMENT OF UBC12 BY AN E2TITL 2 BINDING DOMAIN IN NEDD8S E1.REF MOL.CELL V. 17 341 2005REFN ISSN 1097-2765PMID 15694336DOI 10.1016/J.MOLCEL.2004.12.020 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2yuz MYBPC1 solution structure of 4th immunoglobulin domain of slow type myosin-binding protein c -1.0Å AUTH T.N.NIRAULA,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF 4TH IMMUNOGLOBULIN DOMAIN OFTITL 2 SLOW TYPE MYOSIN-BINDING PROTEIN CREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1i3d HBG1 human carbonmonoxy hemoglobin barts (gamma4) 1.7Å AUTH R.D.KIDD,H.M.BAKER,A.J.MATHEWS,T.BRITTAIN,E.N.BAKERTITL OLIGOMERIZATION AND LIGAND BINDING IN ATITL 2 HOMOTETRAMERIC HEMOGLOBIN: TWO HIGH-RESOLUTIONTITL 3 CRYSTAL STRUCTURES OF HEMOGLOBIN BARTSTITL 4 (GAMMA(4)), A MARKER FOR ALPHA-THALASSEMIA.REF PROTEIN SCI. V. 10 1739 2001REFN ISSN 0961-8368PMID 11514664DOI 10.1110/PS.11701 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2qra XIAP crystal structure of xiap bir1 domain (p21 form) 2.5Å AUTH S.C.LIN,Y.HUANG,Y.C.LO,M.LU,H.WUTITL CRYSTAL STRUCTURE OF THE BIR1 DOMAIN OF XIAP INTITL 2 TWO CRYSTAL FORMSREF J.MOL.BIOL. V. 372 847 2007REFN ISSN 0022-2836PMID 17698078DOI 10.1016/J.JMB.2007.07.019 Variant Set Distributions Mapped Variants
General Structure Information 1wz0 SUMO2 solution structure of human sumo-2 (smt3b), a ubiquitin- like protein -1.0Å AUTH C.ZHAO,K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF HUMAN SUMO-2 (SMT3B), ATITL 2 UBIQUITIN-LIKE PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3dtc MAP3K9 crystal structure of mixed-lineage kinase mlk1 complexed with compound 16 2.6Å AUTH R.L.HUDKINS,J.L.DIEBOLD,M.TAO,K.A.JOSEF,C.H.PARK,AUTH 2 T.S.ANGELES,L.D.AIMONE,J.HUSTEN,M.A.ATOR,S.L.MEYER,AUTH 3 B.P.HOLSKIN,J.T.DURKIN,A.A.FEDOROV,E.V.FEDOROV,AUTH 4 S.C.ALMO,J.R.MATHIASEN,D.BOZYCZKO-COYNE,AUTH 5 M.S.SAPORITO,R.W.SCOTT,J.P.MALLAMOTITL MIXED-LINEAGE KINASE 1 AND MIXED-LINEAGE KINASE 3TITL 2 SUBTYPE-SELECTIVETITL 3 DIHYDRONAPHTHYL[3,4-A]PYRROLO[3,4-C]CARBAZOLE-5-TITL 4 ONES: OPTIMIZATION, MIXED-LINEAGE KINASE 1TITL 5 CRYSTALLOGRAPHY, AND ORAL IN VIVO ACTIVITY INTITL 6 1-METHYL-4-PHENYLTETRAHYDROPYRIDINE MODELS.REF J.MED.CHEM. […]