General Structure Information
| PDB ID | 1th1 |
| HGNC Gene Label(s) | APC |
| Structure Name | beta-catenin in complex with a phosphorylated apc 20aa repeat fragment |
| Resolution | 2.5Å |
| Reference | AUTH Y.XING,W.K.CLEMENTS,I.LE TRONG,T.R.HINDS,AUTH 2 R.STENKAMP,D.KIMELMAN,W.XUTITL CRYSTAL STRUCTURE OF A BETA-CATENIN/APC COMPLEXTITL 2 REVEALS A CRITICAL ROLE FOR APC PHOSPHORYLATION INTITL 3 APC FUNCTION.REF MOL.CELL V. 15 523 2004REFN ISSN 1097-2765PMID 15327769DOI 10.1016/J.MOLCEL.2004.08.001 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 51 |
| Number Of SNVs | 8 |
| Number Of Permutations | 2776 |
| Optimal Distance Threshold | 28.0 |
| K Statistic | 0.25 |
| p-value | 0.056 |
COSMIC
| Number Of Residues | 51 |
| Number Of SNVs | 4 |
| Number Of Permutations | 1153 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.167 |
| p-value | 0.621 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 8 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | -0.179 |
| p-value | 0.869 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
