General Structure Information
| PDB ID | 1mlw |
| HGNC Gene Label(s) | TPH1 |
| Structure Name | crystal structure of human tryptophan hydroxylase with bound 7,8-dihydro-l-biopterin cofactor and fe(iii) |
| Resolution | 1.71Å |
| Reference | AUTH L.WANG,H.ERLANDSEN,J.HAAVIK,P.M.KNAPPSKOG,AUTH 2 R.C.STEVENSTITL THREE-DIMENSIONAL STRUCTURE OF HUMAN TRYPTOPHANTITL 2 HYDROXYLASE AND ITS IMPLICATIONS FOR THETITL 3 BIOSYNTHESIS OF THE NEUROTRANSMITTERS SEROTONINTITL 4 AND MELATONINREF BIOCHEMISTRY V. 41 12569 2002REFN ISSN 0006-2960PMID 12379098DOI 10.1021/BI026561F |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 290 |
| Number Of SNVs | 64 |
| Number Of Permutations | 21034 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.189 |
| p-value | 0.322 |
COSMIC
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 64 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | -0.117 |
| p-value | 0.87 |