General Structure Information
| PDB ID | 1hrf |
| HGNC Gene Label(s) | NRG1 |
| Structure Name | solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erb4 |
| Resolution | -1.0Å |
| Reference | AUTH K.NAGATA,D.KOHDA,H.HATANAKA,S.ICHIKAWA,S.MATSUDA,AUTH 2 T.YAMAMOTO,A.SUZUKI,F.INAGAKITITL SOLUTION STRUCTURE OF THE EPIDERMAL GROWTHTITL 2 FACTOR-LIKE DOMAIN OF HEREGULIN-ALPHA, A LIGANDTITL 3 FOR P180ERBB-4.REF EMBO J. V. 13 3517 1994REFN ISSN 0261-4189PMID 8062828 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 67 |
| Number Of SNVs | 8 |
| Number Of Permutations | 4495 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.214 |
| p-value | 0.278 |
COSMIC
| Number Of Residues | 67 |
| Number Of SNVs | 5 |
| Number Of Permutations | 2524 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.2 |
| p-value | 0.274 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 8 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | -0.25 |
| p-value | 0.097 |